2-Mercapto-5-methoxyimidazole-[4,5-b]pyridine

2-Mercapto-5-methoxyimidazole-[4,5-b]pyridine - Names and Identifiers

Name	2-Mercapto-5-methoxyimidazole-[4,5-b]pyridine
Synonyms	Intermediate of TTZ 2-Mercapto-5-Methoxypyridine 2-Mercapto-5-methoxy-imidazo[4 5-methoxyimidazo-[4,5-b]pyridine-2-thiol 5-Methoxy-3H-imidazo[4,5-b]pyridine-2-thiol 2-MERCAPTO-5-METHOXYIMIDAZOE[4,5-B]PYRIDINE 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine 2-Mercapto-5-methoxyimidazole-[4,5-b]pyridine 2-Mercapto-5-Methoxy-3H-Imidazo[4,5-b]Pyridine 2-Mercapto-5-methoxyimidazole-[4,5-b]pyridine(MIPT) 5-methoxy-1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione 2-MERCAPTO-5-METHOXYIMIDAZOLE-[4,5-B]PYRIDINE(TENATOPRAZOLE INTERMEDIATE) 2-mercapto-5-methoxyimidazole-[4,5-b]pyridine (intermediate of tenatoprazole) 1,3-Dihydro-5-Methoxy-2H-Imidazo(4,5-b)Pyridine-2-Thione 2-mercapto-5-methoxyimidazole-[4,5-b]pyridine
CAS	113713-60-3
EINECS	601-278-1
InChI	InChI=1/C7H7N3OS/c1-11-5-3-2-4-6(9-5)10-7(12)8-4/h2-3H,1H3,(H2,8,9,10,12)

2-Mercapto-5-methoxyimidazole-[4,5-b]pyridine - Physico-chemical Properties

Molecular Formula	C7H7N3OS
Molar Mass	181.21
Density	1.55±0.1 g/cm3(Predicted)
Melting Point	238-241°C
Boling Point	324.9±52.0 °C(Predicted)
Flash Point	144.024°C
Vapor Presure	0mmHg at 25°C
Appearance	White crystal
pKa	7.39±0.40(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.705
MDL	MFCD06658230
Physical and Chemical Properties	White crystals. M.p.234-236. Dissolved in water, ethanol, chloroform.

2-Mercapto-5-methoxyimidazole-[4,5-b]pyridine - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
HS Code	29333990
Hazard Class	IRRITANT

2-Mercapto-5-methoxyimidazole-[4,5-b]pyridine - Reference Information

use

2-mercapto-5-methoxyimidazole [4,5-b] pyridine is a pyridine derivative and can be used as a pharmaceutical intermediate.

Preparation

The synthesis methods of imidazo [4,5-b] pyridine compounds include 2, 3-diaminopyridine and carboxylic acid ring, carbon disulfide or triphosgene ring, 2-chloro-3-aminopyridine and aromatic amine ring, etc. The article uses 6-methoxy -2, 3-diaminopyridine hydrochloride is used as raw material to generate the target product 2-mercapto-5-methoxyimidazole [4,5-b] pyridine [1] through ring closure with carbon disulfide. the synthesis route is shown in the figure:

Last Update：2024-04-09 02:00:06